Table II.6. Applications of site-specific recombination to different functions in bacterial cells. (Hallet and Sherratt 1997) |
Integrate infecting viral genomes, which can later be excised by site-specific recombination (Groth and Calos 2004; Smith, Brown et al. 2010). |
Integrate horizontally transferred DNA segments (genomic islands) (Manson and Gilmore 2006; Wilde, Mazel et al. 2008; Juhas, van der Meer et al. 2009). |
Integrate and excise single-protein coding cassettes for antibiotic resistance and other cell properties into expression structures called “integrons” or (in the case of very large structures encoding diverse proteins) “super-integrons” (Hall and Collis 1995; Rowe-Magnus, Guérout et al. 1999; Rowe-Magnus, Guerout et al. 2002; Rowe-Magnus and Mazel 2002). |
Separating intermediate structures in the movement of DNA transposons (Derbyshire and Grindley 1986; Brown and Evans 1991; Olorunniji and Stark 2010). |
Resolve tandemly repeated chromosomes and smaller replicons into two separate molecules for proper distribution to daughter cells (Barre, Soballe et al. 2001; Sherratt, Soballe et al. 2004). |
Resolve replicated telomeres on prokaryotic linear chromosomes (Kobryn and Chaconas 2001; Tourand, Lee et al. 2007; Chaconas and Kobryn 2010). |
Invert DNA segments to regulate transcription (see Table II.5). |
Invert DNA segments to alter protein coding sequences (see Table II.5). |
Excise “DNA introns” to permit the expression of specialized functions in terminally differentiated bacterial cells (see Table II.5). |
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