James A. Shapiro Curriculum Vitae Publications Blogs Bacteria Genome Engineering Evolution: A view from the 21st Century (June 2011) Courses Contact Me

Transgenerational Epigenetic Effects

(Jablonka 2005; Anway, Leathers et al. 2006; Anway and Skinner 2006; Chang, Anway et al. 2006; Koturbash, Baker et al. 2006; Boyko, Kathiria et al. 2007; Jablonka and Lamb 2007; Kaati, Bygren et al. 2007; Anway and Skinner 2008; Dubrova, Hickenbotham et al. 2008; Morgan and Whitelaw 2008; Nilsson, Anway et al. 2008; Skinner, Anway et al. 2008; Whitelaw and Whitelaw 2008; Youngson and Whitelaw 2008; Guerrero-Bosagna and Skinner 2009; Jablonka and Raz 2009; Nadeau 2009; Pecinka, Rosa et al. 2009; Sharma and Singh 2009; Skinner and Guerrero-Bosagna 2009; Wang, Chai et al. 2009; Boyko, Blevins et al. 2010; Boyko and Kovalchuk 2010; Cuzin and Rassoulzadegan 2010; Daxinger and Whitelaw 2010; Ho and Burggren 2010; Lang-Mladek, Popova et al. 2010; Pembrey 2010; Skinner, Manikkam et al. 2010; Burdge, Hoile et al. 2011; Gissis and Jablonka 2011; Greer, Maures et al. 2011; Hauser, Aufsatz et al. 2011; Herman and Sultan 2011; Ito, Gaubert et al. 2011; Paszkowski and Grossniklaus 2011; Rahavi, Migicovsky et al. 2011; Rechavi, Minevich et al. 2011; Schmitz, Schultz et al. 2011; Daxinger and Whitelaw 2012; Herman, Sultan et al. 2012; Manikkam, Guerrero-Bosagna et al. 2012; Nilsson, Larsen et al. 2012; Verhoeven and van Gurp 2012; Zucchi, Yao et al. 2012)

REFERENCES

Anway, M. D., C. Leathers, et al. (2006). "Endocrine disruptor vinclozolin induced epigenetic transgenerational adult-onset disease." Endocrinology 147(12): 5515-5523. http://www.ncbi.nlm.nih.gov/pubmed/16973726.

Anway, M. D. and M. K. Skinner (2006). "Epigenetic transgenerational actions of endocrine disruptors." Endocrinology 147(6 Suppl): S43-49. http://www.ncbi.nlm.nih.gov/pubmed/16690803.

Anway, M. D. and M. K. Skinner (2008). "Transgenerational effects of the endocrine disruptor vinclozolin on the prostate transcriptome and adult onset disease." Prostate 68(5): 517-529. http://www.ncbi.nlm.nih.gov/pubmed/18220299.

Boyko, A., T. Blevins, et al. (2010). "Transgenerational adaptation of Arabidopsis to stress requires DNA methylation and the function of Dicer-like proteins." PLoS One 5(3): e9514. http://www.ncbi.nlm.nih.gov/pubmed/20209086.

Boyko, A., P. Kathiria, et al. (2007). "Transgenerational changes in the genome stability and methylation in pathogen-infected plants: (virus-induced plant genome instability)." Nucleic Acids Res 35(5): 1714-1725. http://www.ncbi.nlm.nih.gov/pubmed/17311811.

Boyko, A. and I. Kovalchuk (2010). "Transgenerational response to stress in Arabidopsis thaliana." Plant Signal Behav 5(8). http://www.ncbi.nlm.nih.gov/pubmed/20724818.

Burdge, G. C., S. P. Hoile, et al. (2011). "Progressive, transgenerational changes in offspring phenotype and epigenotype following nutritional transition." PLoS One 6(11): e28282. http://www.ncbi.nlm.nih.gov/pubmed/22140567.

Chang, H. S., M. D. Anway, et al. (2006). "Transgenerational epigenetic imprinting of the male germline by endocrine disruptor exposure during gonadal sex determination." Endocrinology 147(12): 5524-5541. http://www.ncbi.nlm.nih.gov/pubmed/16973722.

Cuzin, F. and M. Rassoulzadegan (2010). "Non-Mendelian epigenetic heredity: gametic RNAs as epigenetic regulators and transgenerational signals." Essays Biochem 48(1): 101-106. http://www.ncbi.nlm.nih.gov/pubmed/20822489.

Daxinger, L. and E. Whitelaw (2010). "Transgenerational epigenetic inheritance: more questions than answers." Genome Res 20(12): 1623-1628. http://www.ncbi.nlm.nih.gov/pubmed/21041414.

Daxinger, L. and E. Whitelaw (2012). "Understanding transgenerational epigenetic inheritance via the gametes in mammals." Nat Rev Genet 13(3): 153-162. http://www.ncbi.nlm.nih.gov/pubmed/22290458.

Dubrova, Y. E., P. Hickenbotham, et al. (2008). "Paternal exposure to ethylnitrosourea results in transgenerational genomic instability in mice." Environ Mol Mutagen 49(4): 308-311. http://www.ncbi.nlm.nih.gov/pubmed/18366099.

Gissis, S. B. and E. Jablonka, Eds. (2011). Transformations of Lamarckism: from Subtle Fluids to Molecular Biology. Cambridge, MA, MIT Press. .

Greer, E. L., T. J. Maures, et al. (2011). "Transgenerational epigenetic inheritance of longevity in Caenorhabditis elegans." Nature. http://www.ncbi.nlm.nih.gov/pubmed/22012258.

Guerrero-Bosagna, C. M. and M. K. Skinner (2009). "Epigenetic transgenerational effects of endocrine disruptors on male reproduction." Semin Reprod Med 27(5): 403-408. http://www.ncbi.nlm.nih.gov/pubmed/19711250.

Hauser, M. T., W. Aufsatz, et al. (2011). "Transgenerational epigenetic inheritance in plants." Biochim Biophys Acta 1809(8): 459-468. http://www.ncbi.nlm.nih.gov/pubmed/21515434.

Herman, J. J. and S. E. Sultan (2011). "Adaptive transgenerational plasticity in plants: case studies, mechanisms, and implications for natural populations." Front Plant Sci 2: 102. http://www.ncbi.nlm.nih.gov/pubmed/22639624.

Herman, J. J., S. E. Sultan, et al. (2012). "Adaptive transgenerational plasticity in an annual plant: grandparental and parental drought stress enhance performance of seedlings in dry soil." Integr Comp Biol 52(1): 77-88. http://www.ncbi.nlm.nih.gov/pubmed/22523124.

Ho, D. H. and W. W. Burggren (2010). "Epigenetics and transgenerational transfer: a physiological perspective." J Exp Biol\ 213\(1\): 3-16\. http://www.ncbi.nlm.nih.gov/pubmed/20008356\.

Ito, H., H. Gaubert, et al. (2011). "An siRNA pathway prevents transgenerational retrotransposition in plants subjected to stress." Nature. http://www.ncbi.nlm.nih.gov/pubmed/21399627.

Jablonka, E. and M. J. Lamb (2007). "Precis of Evolution in Four Dimensions." Behav Brain Sci 30(4): 353-365; discusssion 365-389. http://www.ncbi.nlm.nih.gov/pubmed/18081952.

Jablonka, E., Lamb, M (2005). Evolution in Four Dimensions. Boston, MIT Press. .

Jablonka, E. and G. Raz (2009). "Transgenerational epigenetic inheritance: prevalence, mechanisms, and implications for the study of heredity and evolution." Q Rev Biol 84(2): 131-176. http://www.ncbi.nlm.nih.gov/pubmed/19606595.

Kaati, G., L. O. Bygren, et al. (2007). "Transgenerational response to nutrition, early life circumstances and longevity." Eur J Hum Genet 15(7): 784-790. http://www.ncbi.nlm.nih.gov/pubmed/17457370.

Koturbash, I., M. Baker, et al. (2006). "Epigenetic dysregulation underlies radiation-induced transgenerational genome instability in vivo." Int J Radiat Oncol Biol Phys 66(2): 327-330. http://www.ncbi.nlm.nih.gov/pubmed/16965987.

Lang-Mladek, C., O. Popova, et al. (2010). "Transgenerational inheritance and resetting of stress-induced loss of epigenetic gene silencing in Arabidopsis." Mol Plant 3(3): 594-602. http://www.ncbi.nlm.nih.gov/pubmed/20410255.

Manikkam, M., C. Guerrero-Bosagna, et al. (2012). "Transgenerational actions of environmental compounds on reproductive disease and identification of epigenetic biomarkers of ancestral exposures." PLoS One 7(2): e31901. http://www.ncbi.nlm.nih.gov/pubmed/22389676.

Morgan, D. K. and E. Whitelaw (2008). "The case for transgenerational epigenetic inheritance in humans." Mamm Genome\ 19\(6\): 394-397\. http://www.ncbi.nlm.nih.gov/pubmed/18663528\.

Nadeau, J. H. (2009). "Transgenerational genetic effects on phenotypic variation and disease risk." Hum Mol Genet\ 18\(R2\): R202-210\. http://www.ncbi.nlm.nih.gov/pubmed/19808797\.

Nilsson, E., G. Larsen, et al. (2012). "Environmentally induced epigenetic transgenerational inheritance of ovarian disease." PLoS One 7(5): e36129. http://www.ncbi.nlm.nih.gov/pubmed/22570695.

Nilsson, E. E., M. D. Anway, et al. (2008). "Transgenerational epigenetic effects of the endocrine disruptor vinclozolin on pregnancies and female adult onset disease." Reproduction 135(5): 713-721. http://www.ncbi.nlm.nih.gov/pubmed/18304984.

Paszkowski, J. and U. Grossniklaus (2011). "Selected aspects of transgenerational epigenetic inheritance and resetting in plants." Curr Opin Plant Biol 14(2): 195-203. http://www.ncbi.nlm.nih.gov/pubmed/21333585.

Pecinka, A., M. Rosa, et al. (2009). "Transgenerational stress memory is not a general response in Arabidopsis." PLoS One\ 4\(4\): e5202\. http://www.ncbi.nlm.nih.gov/pubmed/19381297\.

Pembrey, M. E. (2010). "Male-line transgenerational responses in humans." Hum Fertil (Camb) 13(4): 268-271. http://www.ncbi.nlm.nih.gov/pubmed/21117937.

Rahavi, M. R., Z. Migicovsky, et al. (2011). "Transgenerational adaptation to heavy metal salts in Arabidopsis." Front Plant Sci 2: 91. http://www.ncbi.nlm.nih.gov/pubmed/22639617.

Rechavi, O., G. Minevich, et al. (2011). "Transgenerational inheritance of an acquired small RNA-based antiviral response in C. elegans." Cell 147(6): 1248-1256. http://www.ncbi.nlm.nih.gov/pubmed/22119442.

Schmitz, R. J., M. D. Schultz, et al. (2011). "Transgenerational epigenetic instability is a source of novel methylation variants." Science 334(6054): 369-373. http://www.ncbi.nlm.nih.gov/pubmed/21921155.

Sharma, A. and P. Singh (2009). "Detection of transgenerational spermatogenic inheritance of adult male acquired CNS gene expression characteristics using a Drosophila systems model." PLoS One 4(6): e5763. http://www.ncbi.nlm.nih.gov/pubmed/19503609.

Skinner, M. K., M. D. Anway, et al. (2008). "Transgenerational epigenetic programming of the brain transcriptome and anxiety behavior." PLoS One 3(11): e3745. http://www.ncbi.nlm.nih.gov/pubmed/19015723.

Skinner, M. K. and C. Guerrero-Bosagna (2009). "Environmental signals and transgenerational epigenetics." Epigenomics 1(1): 111-117. http://www.ncbi.nlm.nih.gov/pubmed/20563319.

Skinner, M. K., M. Manikkam, et al. (2010). "Epigenetic transgenerational actions of environmental factors in disease etiology." Trends Endocrinol Metab 21(4): 214-222. http://www.ncbi.nlm.nih.gov/pubmed/20074974\.

Verhoeven, K. J. and T. P. van Gurp (2012). "Transgenerational effects of stress exposure on offspring phenotypes in apomictic dandelion." PLoS One 7(6): e38605. http://www.ncbi.nlm.nih.gov/pubmed/22723869.

Wang, H., Y. Chai, et al. (2009). "Molecular characterization of a rice mutator-phenotype derived from an incompatible cross-pollination reveals transgenerational mobilization of multiple transposable elements and extensive epigenetic instability." BMC Plant Biol 9: 63. http://www.ncbi.nlm.nih.gov/pubmed/19476655.

Whitelaw, N. C. and E. Whitelaw (2008). "Transgenerational epigenetic inheritance in health and disease." Curr Opin Genet Dev\ 18\(3\): 273-279\. http://www.ncbi.nlm.nih.gov/pubmed/18662779\.

Youngson, N. A. and E. Whitelaw (2008). "Transgenerational epigenetic effects." Annu Rev Genomics Hum Genet\ 9\: 233-257\. http://www.ncbi.nlm.nih.gov/pubmed/18767965\.

Zucchi, F. C., Y. Yao, et al. (2012). "The secret language of destiny: stress imprinting and transgenerational origins of disease." Front Genet 3: 96. http://www.ncbi.nlm.nih.gov/pubmed/22675331.