[ James A. Shapiro ] James A. Shapiro

Somatic hypermutation

(Cascalho, Wong et al. 1998; Zan, Cerutti et al. 1999; Muramatsu, Kinoshita et al. 2000; Kinoshita and Honjo 2001; Honjo, Kinoshita et al. 2002; Papavasiliou and Schatz 2002; Diaz, Ray et al. 2003; Dickerson, Market et al. 2003; Li, Woo et al. 2004; Shinkura, Ito et al. 2004; Goodman and Scharff 2005; Odegard, Kim et al. 2005; Seki, Gearhart et al. 2005; Casali, Pal et al. 2006; Inlay, Gao et al. 2006; Longerich, Basu et al. 2006; Odegard and Schatz 2006; Yang, Fugmann et al. 2006; Di Noia and Neuberger 2007; Teng and Papavasiliou 2007; Arakawa, Kudo et al. 2008; Chezar, Lobel-Lavi et al. 2008; Longo, Satorius et al. 2008; Peled, Kuang et al. 2008; Steele 2008; Arakawa and Buerstedde 2009; Blagodatski, Batrak et al. 2009; Dunnick, Collins et al. 2009; Hackney, Misaghi et al. 2009; Liu and Schatz 2009; Park, Zan et al. 2009; Reynaud, Delbos et al. 2009; Sale, Batters et al. 2009; Steele 2009; Maul and Gearhart 2010; Maul and Gearhart 2010; Tanaka, Shen et al. 2010; Wei, Shinkura et al. 2011)



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Casali, P., Z. Pal, et al. (2006). "DNA repair in antibody somatic hypermutation." Trends Immunol 27(7): 313-321. http://www.ncbi.nlm.nih.gov/pubmed/16737852.

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Chezar, I., L. Lobel-Lavi, et al. (2008). "Ongoing somatic hypermutation of the rearranged VH but not of the V-lambda gene in EBV-transformed rheumatoid factor-producing lymphoblastoid cell line." Mol Immunol 46(1): 80-90. http://www.ncbi.nlm.nih.gov/pubmed/18718665.

Di Noia, J. M. and M. S. Neuberger (2007). "Molecular mechanisms of antibody somatic hypermutation." Annu Rev Biochem 76: 1-22. http://www.ncbi.nlm.nih.gov/pubmed/17328676.

Diaz, M., M. Ray, et al. (2003). "Mutagenesis by AID, a molecule critical to immunoglobulin hypermutation, is not caused by an alteration of the precursor nucleotide pool." Mol Immunol 40(5): 261-268. http://www.ncbi.nlm.nih.gov/pubmed/12943798.

Dickerson, S. K., E. Market, et al. (2003). "AID mediates hypermutation by deaminating single stranded DNA." J Exp Med\ 197\(10\): 1291-1296\. http://www.ncbi.nlm.nih.gov/pubmed/12756266\.

Dunnick, W. A., J. T. Collins, et al. (2009). "Switch recombination and somatic hypermutation are controlled by the heavy chain 3' enhancer region." J Exp Med 206(12): 2613-2623. http://www.ncbi.nlm.nih.gov/pubmed/19887393.

Goodman, M. F. and M. D. Scharff (2005). "Identifying protein-protein interactions in somatic hypermutation." J Exp Med\ 201\(4\): 493-496\. http://www.ncbi.nlm.nih.gov/pubmed/15710655\.

Hackney, J. A., S. Misaghi, et al. (2009). "DNA targets of AID evolutionary link between antibody somatic hypermutation and class switch recombination." Adv Immunol 101: 163-189. http://www.ncbi.nlm.nih.gov/pubmed/19231595.

Honjo, T., K. Kinoshita, et al. (2002). "Molecular mechanism of class switch recombination: linkage with somatic hypermutation." Annu Rev Immunol 20: 165-196. http://www.ncbi.nlm.nih.gov/pubmed/11861601.

Inlay, M. A., H. H. Gao, et al. (2006). "Roles of the Ig kappa light chain intronic and 3' enhancers in Igk somatic hypermutation." J Immunol 177(2): 1146-1151. http://www.ncbi.nlm.nih.gov/pubmed/16818772.

Kinoshita, K. and T. Honjo (2001). "Linking class-switch recombination with somatic hypermutation." Nat Rev Mol Cell Biol 2(7): 493-503. http://www.ncbi.nlm.nih.gov/pubmed/11433363.

Li, Z., C. J. Woo, et al. (2004). "The generation of antibody diversity through somatic hypermutation and class switch recombination." Genes Dev 18(1): 1-11. http://www.ncbi.nlm.nih.gov/pubmed/14724175.

Liu, M. and D. G. Schatz (2009). "Balancing AID and DNA repair during somatic hypermutation." Trends Immunol\ 30(4): 173-181. http://www.ncbi.nlm.nih.gov/pubmed/19303358.

Longerich, S., U. Basu, et al. (2006). "AID in somatic hypermutation and class switch recombination." Curr Opin Immunol 18(2): 164-174. http://www.ncbi.nlm.nih.gov/pubmed/16464563.

Longo, N. S., C. L. Satorius, et al. (2008). "Characterization of Ig gene somatic hypermutation in the absence of activation-induced cytidine deaminase." J Immunol 181(2): 1299-1306. http://www.ncbi.nlm.nih.gov/pubmed/18606684.

Maul, R. W. and P. J. Gearhart (2010). "AID and somatic hypermutation." Adv Immunol 105: 159-191. http://www.ncbi.nlm.nih.gov/pubmed/20510733.

Maul, R. W. and P. J. Gearhart (2010). "Controlling somatic hypermutation in immunoglobulin variable and switch regions." Immunol Res 47(1-3): 113-122. http://www.ncbi.nlm.nih.gov/pubmed/20082153.

Muramatsu, M., K. Kinoshita, et al. (2000). "Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme." Cell 102(5): 553-563. http://www.ncbi.nlm.nih.gov/pubmed/11007474.

Odegard, V. H., S. T. Kim, et al. (2005). "Histone modifications associated with somatic hypermutation." Immunity 23(1): 101-110. http://www.ncbi.nlm.nih.gov/pubmed/16039583.

Odegard, V. H. and D. G. Schatz (2006). "Targeting of somatic hypermutation." Nat Rev Immunol 6(8): 573-583. http://www.ncbi.nlm.nih.gov/pubmed/16868548.

Papavasiliou, F. N. and D. G. Schatz (2002). "Somatic hypermutation of immunoglobulin genes: merging mechanisms for genetic diversity." Cell 109 Suppl: S35-44. http://www.ncbi.nlm.nih.gov/pubmed/11983151.

Park, S. R., H. Zan, et al. (2009). "HoxC4 binds to the promoter of the cytidine deaminase AID gene to induce AID expression, class-switch DNA recombination and somatic hypermutation." Nat Immunol 10(5): 540-550. http://www.ncbi.nlm.nih.gov/pubmed/19363484.

Peled, J. U., F. L. Kuang, et al. (2008). "The biochemistry of somatic hypermutation." Annu Rev Immunol\ 26\: 481-511\. http://www.ncbi.nlm.nih.gov/pubmed/18304001\.

Reynaud, C. A., F. Delbos, et al. (2009). "Competitive repair pathways in immunoglobulin gene hypermutation." Philos Trans R Soc Lond B Biol Sci\ 364\(1517\): 613-619\. http://www.ncbi.nlm.nih.gov/pubmed/19010770\.

Sale, J. E., C. Batters, et al. (2009). "Timing matters: error-prone gap filling and translesion synthesis in immunoglobulin gene hypermutation." Philos Trans R Soc Lond B Biol Sci 364(1517): 595-603. http://www.ncbi.nlm.nih.gov/pubmed/19008194.

Seki, M., P. J. Gearhart, et al. (2005). "DNA polymerases and somatic hypermutation of immunoglobulin genes." EMBO Rep 6(12): 1143-1148. http://www.ncbi.nlm.nih.gov/pubmed/16319960.

Shinkura, R., S. Ito, et al. (2004). "Separate domains of AID are required for somatic hypermutation and class-switch recombination." Nat Immunol 5(7): 707-712. http://www.ncbi.nlm.nih.gov/pubmed/15195091.

Steele, E. J. (2008). "Reflections on the state of play in somatic hypermutation." Mol Immunol 45(10): 2723-2726. http://www.ncbi.nlm.nih.gov/pubmed/18359085.

Steele, E. J. (2009). "Mechanism of somatic hypermutation: critical analysis of strand biased mutation signatures at A:T and G:C base pairs." Mol Immunol 46(3): 305-320. http://www.ncbi.nlm.nih.gov/pubmed/19062097.

Tanaka, A., H. M. Shen, et al. (2010). "Attracting AID to targets of somatic hypermutation." J Exp Med 207(2): 405-415. http://www.ncbi.nlm.nih.gov/pubmed/20100870.

Teng, G. and F. N. Papavasiliou (2007). "Immunoglobulin somatic hypermutation." Annu Rev Genet\ 41\: 107-120\. http://www.ncbi.nlm.nih.gov/pubmed/17576170\.

Wei, M., R. Shinkura, et al. (2011). "Mice carrying a knock-in mutation of Aicda resulting in a defect in somatic hypermutation have impaired gut homeostasis and compromised mucosal defense." Nat Immunol 12(3): 264-270. http://www.ncbi.nlm.nih.gov/pubmed/21258321.

Yang, S. Y., S. D. Fugmann, et al. (2006). "Control of gene conversion and somatic hypermutation by immunoglobulin promoter and enhancer sequences." J Exp Med 203(13): 2919-2928. http://www.ncbi.nlm.nih.gov/pubmed/17178919.

Zan, H., A. Cerutti, et al. (1999). "Induction of Ig somatic hypermutation and class switching in a human monoclonal IgM+ IgD+ B cell line in vitro: definition of the requirements and modalities of hypermutation." J Immunol 162(6): 3437-3447. http://www.ncbi.nlm.nih.gov/pubmed/10092799.