Distinct
Classes
Of DNA In
The Genome
(Wood, Gwilliam et
al. 2002; Mrazek 2009; Janes, Organ et al.
2010; Mrazek 2010; Romiguier, Ranwez
et al. 2010)
Triplet code, other codes, nested
coding sequences
and overlapping messages embedded in coding sequences
(Sanger, Air et al.
1977; Van der Avoort,
Teertstra et al.
1983; Tramontano,
Scarlato et al. 1984; Merino, Balbas et
al. 1994; Trifonov 1999; Konecny, Schoniger
et al. 2000; Peleg, Trifonov et
al. 2003; Hosid, Trifonov et
al. 2004; Johnson and
Chisholm 2004; Peleg, Kirzhner et
al. 2004; Makalowska, Lin et
al. 2005; Cohanim, Trifonov
et al. 2006; Firth and Brown
2006; Gabdank, Barash et
al. 2006; Zhu and Freeland
2006; Bollenbach,
Vetsigian et al. 2007; Itzkovitz and Alon
2007; Assis, Kondrashov
et al. 2008; Chung, Miller et
al. 2008; Delaye, Deluna et
al. 2008; Robins, Krasnitz et
al. 2008; Sabath, Graur et
al. 2008; Salih, Salih et al.
2008; Sanna, Li et al.
2008; Wang, Barr et al.
2008; Bettecken and
Trifonov 2009; Kumar 2009; Ma and Nussinov
2009; Prat, Fromer et al.
2009; Woltering and
Duboule 2009; Cheng, Yang et al.
2010; Chirico, Vianelli
et al. 2010; Itzkovitz, Hodis et
al. 2010; Sabath and Graur
2010; Firth, Wills et al.
2011; Hudson, Gu et al.
2011; Sanjuan and
Borderia 2011; Trifonov 2011)
(Lin, Kheradpour et
al. 2011) (“We collect numerous lines of evidence that the observed
synonymous
constraint in these regions reflects selection on overlapping
functional
elements including splicing regulatory elements, dual-coding
genes, RNA
secondary structures, microRNA target sites, and developmental
enhancers. Our
results show that overlapping
functional
elements are common in mammalian genes, despite the vast
genomic landscape.”)
Ribosomal
frameshifting to elongate fusion
proteins: (Ivanov, Gesteland
et al. 2000; Ivanov and Atkins
2007; Jacobs, Belew et
al. 2007; Belew, Hepler et
al. 2008; Chou, Lin et al.
2010; Firth, Blitvich et
al. 2010)
Heterochromatin
(Passarge 1979; Karpen 1994; Weiler and Wakimoto
1995; Zacharias 1995; Henikoff 2000; Lohe and Roberts
2000; Grewal and Elgin
2002; Pidoux and Allshire
2005; Scott, Merrett et
al. 2006; Carchilan, Delgado
et al. 2007; Durand-Dubief and
Ekwall 2008; Ishii, Ogiyama et
al. 2008; Ferree and Barbash
2009; Hughes and Hawley
2009; Kotnova, Salenko et
al. 2009; Las Penas,
Urdampilleta et al. 2009; Guetg, Lienemann et
al. 2010; Martienssen 2010; Tamaru 2010)
“Non-coding” (“nc”) sequences
(Mattick 2001; Puertas 2002; Sleutels, Zwart et
al. 2002; Shabalina and
Spiridonov 2004; Gottesman 2005; Lockton and Gaut
2005; Tang, Polacek et
al. 2005; Woolfe, Goodson et
al. 2005; Goodrich and Kugel
2006; Ponting and Lunter
2006; Westenberger,
Cerqueira et al. 2006; Mikkelsen,
Wakefield et al. 2007; Vavouri, Walter et
al. 2007; Costa 2008; Glinsky 2008; Royo and Cavaille
2008; Swiercz, Hindra et
al. 2008; Tomilin 2008; Warnecke, Parmley
et al. 2008; Blombach, Makarova
et al. 2009; Bradley, Uzilov et
al. 2009; Collins and Penny
2009; Duharcourt, Lepere
et al. 2009; Forrest, Abdelhamid
et al. 2009; Gieni and Hendzel
2009; Guttman, Amit et
al. 2009; Hirota and Ohta
2009; Koerner, Pauler et
al. 2009; Leeb, Steffen et
al. 2009; Mercer, Dinger et
al. 2009; Morris 2009; Morris 2009; Morris 2009; Navarro, Chantalat
et al. 2009; Ponjavic, Oliver et
al. 2009; Qureshi and Mehler
2009; Tuller, Ruppin et
al. 2009; Bousios, Darzentas
et al. 2010; Kapranov, St
Laurent et al. 2010; Malecova and Morris
2010; Matsunami, Sumiyama
et al. 2010; Pennisi 2010; Schoeftner and
Blasco 2010; Subirana and
Messeguer 2010; van Leeuwen and
Mikkers 2010; Zhou, Hu et al.
2010; Gibb, Brown et al.
2011; Janes, Chapus et
al. 2011; Orom and
Shiekhattar 2011; Pek and Kai 2011)
Segmental duplications
(Samonte and Eichler
2002; Armengol, Pujana et
al. 2003; Newman and Trask
2003; Stankiewicz, Shaw
et al. 2004; Armengol,
Marques-Bonet et al. 2005; Sharp, Locke et al.
2005; Bailey and Eichler
2006; Coulibaly, Lobo et
al. 2007; Darai-Ramqvist,
Sandlund et al. 2008; She, Cheng et al.
2008; Koszul and Fischer
2009; Marques-Bonet,
Girirajan et al. 2009; Marques-Bonet, Kidd
et al. 2009)
Inversions
(Lyttle and Haymer
1992; Caceres, Ranz et
al. 1999; Mathiopoulos, della
Torre et al.
1999; Singh 2001; Kuwahara, Yamashita
et al. 2004; Puig, Caceres et
al. 2004; Cerdeno-Tarraga,
Patrick et al. 2005; Caceres, Sullivan
et al. 2007; Coulibaly, Lobo et
al. 2007; Tsuji, Ueda et al.
2007; Hoffmann and
Rieseberg 2008; Delprat, Negre et
al. 2009; Kojima and Okada
2009; Kolb, Chuzhanova et
al. 2009; Swenson and Moret
2009; Kirkpatrick 2010; Kugelberg, Kofoid
et al. 2010; Ling and Cordaux
2010; Lobo, Sangare et
al. 2010; Lowry and Willis
2010; Furuta, Kawai et
al. 2011)
Mobile genetic elements
(Smit 1999; Craig 2002; Gentles, Wakefield
et al. 2007; Kordis 2009)
Retrotransposons and
retrotransduced
sequences: (Noma, Ohtsubo et
al. 1999; Schmidt 1999; Gilbert and Labuda
2000; Ogiwara, Miya et
al. 2002; Cardazzo,
Bargelloni et al. 2003; Duvernell, Pryor et
al. 2004; DeCerbo and
Carmichael 2005; Kramerov and
Vassetzky 2005; Schmitz, Roos et
al. 2005; Wang, Xing et al.
2005; Kejnovsky, Kubat et
al. 2006; Kordis, Lovsin et
al. 2006; Piskurek, Austin et
al. 2006; Gu, Ray et al. 2007; Kriegs, Churakov et
al. 2007; Lee, Cordaux et al.
2007; Moller-Krull,
Delsuc et al. 2007; Onami, Nikaido et
al. 2007; Akagi, Li et al.
2008; Kojima and Kanehisa
2008; Nishihara and Okada
2008; Wang and Liu 2008; Hirakawa, Nishihara
et al. 2009; Matveev and Okada
2009; Ray, Platt et al.
2009; Smykal, Kalendar et
al. 2009; Walters, Kugel et
al. 2009; Cioffi, Martins et
al. 2010; Kawakami, Strakosh
et al. 2010; Novikova,
Smyshlyaev et al. 2010; Ragupathy, Banks et
al. 2010; Neumann,
Navratilova et al. 2011)
DNA transposons: (Lovering, Harden et
al. 1991; Poulter, Goodwin et
al. 2003; Dooner and Weil
2007; Ray, Feschotte et
al. 2008; Bao, Jurka et al.
2009; Bao, Kapitonov et
al. 2010; Cioffi, Martins et
al. 2010; Tomita, Okutani et
al. 2011)
Repeats/repetitive DNA
(Orgel 1980; Wostemeyer and
Kreibich 2002; Jurka, Kapitonov et
al. 2007; Cermak, Kubat et
al. 2008; Doggett 2008; Kazama and
Matsunaga 2008; Lorenzi,
Thiagarajan et al. 2008; Otto, Gomes et al.
2008; Richard, Kerrest et
al. 2008; Wang, Lorenzen et
al. 2008; Kejnovsky, Hobza et
al. 2009; Cioffi, Martins et
al. 2010; Cioffi, Martins et
al. 2010; Habu 2010; Mravinac and Plohl
2010; O'Meally, Patel et
al. 2010; Castoe, Hall et al.
2011; Cioffi, Camacho et
al. 2011; Cioffi, Molina et
al. 2011; de Koning, Gu et
al. 2011; Delihas 2011; Pearson 2011)
Dispersed repeats (Kordis and Gubensek
1998; Borodulina and
Kramerov 1999; Smit 1999; Herman and
Heyndrickx 2000; Smith, Bringaud et
al. 2009; Zhao, Qi et al.
2009; Clayton 2010; Tempel, Rousseau et
al. 2010; Tomita, Okutani et
al. 2011)
Ultraconserved elements: (Bejerano, Pheasant
et al. 2004; Sandelin, Bailey et
al. 2004; Glazov, Pheasant et
al. 2005; Poulin, Nobrega et
al. 2005; Siepel, Bejerano et
al. 2005; Woolfe, Goodson et
al. 2005; Bejerano, Lowe et
al. 2006; Derti, Roth et al.
2006; Gardiner, Hirons et
al. 2006; Papatsenko, Kislyuk
et al. 2006; Venkatesh, Kirkness
et al. 2006; Ahituv, Zhu et al.
2007; Chen, Wang et al.
2007; Katzman, Kern et
al. 2007; Lareau, Inada et
al. 2007; Ni, Grate et al.
2007; Vavouri, Walter et
al. 2007; Voss, Gierga et al.
2007; Baira, Greshock et
al. 2008; Chen, Gottlieb et
al. 2008; Chiang, Derti et
al. 2008; Elgar and Vavouri
2008; Hickey 2008; Lin, Ma et al. 2008; McLean and Bejerano
2008; Ovcharenko 2008; Sakuraba, Kimura et
al. 2008; Stephen, Pheasant
et al. 2008; Visel, Prabhakar et
al. 2008; Woolfe and Elgar
2008; Zheng and Zhang
2008; Rodelsperger,
Kohler et al. 2009; Vavouri and Lehner
2009; Vavouri, Semple et
al. 2009; Wang, Lee et al.
2009; Amiel, Benko et al.
2010; Licastro, Gennarino
et al. 2010; Martinez, Monfort
et al. 2010; Ni, Shu et al. 2010; Tran, Wong et al.
2010; Woolfe, Mullikin et
al. 2010; Cheong and Lufkin
2011; Halligan, Oliver et
al. 2011; Lee, Kerk et al.
2011; McCormack,
Faircloth et al. 2011; Sathirapongsasuti,
Sathira et al.
2011; Tashiro, Teissier
et al. 2011)
Tandem repeats
(“satellites”) and
microsatellites: (Csink and Henikoff
1998; Motta, Landsberger
et al. 1998; Schlotterer 2000; Bois 2003; Muegge 2005; Grechko, Ciobanu et
al. 2006; Hobza, Lengerova et
al. 2006; Anmarkrud, Kleven
et al. 2008; Cermak, Kubat et
al. 2008; Kazama and
Matsunaga 2008; Plohl, Luchetti et
al. 2008; Tomilin 2008; Adega, Guedes-Pinto
et al. 2009; Chadwick 2009; Eckert and Hile
2009; Kejnovsky, Hobza et
al. 2009; Kuhn, Teo et al.
2009; Macas, Koblizkova
et al. 2009; Pemberton, Sandefur
et al. 2009; Castagnone-Sereno,
Danchin et al.
2010; Nakamori and
Thornton 2010; Rolland, Dujon et
al. 2010; Rosloski, Jali et
al. 2010; Thierry, Dujon et
al. 2010; Tremblay, Alexander
et al. 2010; Vicari, Nogaroto et
al. 2010; Cioffi, Kejnovsky
et al. 2011; Lam, Wu et al. 2011; Payseur, Jing et
al. 2011; Pokorna, Kratochvil
et al. 2011; Smith, Bomblies et
al. 2011; Wojciechowska and
Krzyzosiak 2011; Zu, Gibbens et al.
2011)
Simple sequence repeats: (Kashi and King 2006; Cuadrado, Cardoso
et al. 2008; Fondon, Hammock et
al. 2008; Saurabh, Sneha et
al. 2011)
Coding sequence repeats: (Naamati, Fromer et
al. 2009)
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