Cell Cycle
Checkpoints
(Hartwell 1989; Hartwell 1992; Elledge 1996; Hartwell 2004; Hansen and Schedl
2006; Fuller and
Stukenberg 2009; Game and
Chernikova 2009; McAdams and
Shapiro 2009)
Replication checkpoint
(Weinert 1992; D'Urso, Grallert
et al. 1995; Navas, Zhou et
al. 1995; Paulovich and
Hartwell 1995; Sclafani and
Holzen 2007; Ciapponi and
Cenci 2008; Branzei and
Foiani 2009; Putnam, Jaehnig
et al. 2009; Segurado and
Tercero 2009; Voineagu,
Freudenreich et al. 2009; Clelland and
Schultz 2010; Nguyen, Clelland
et al. 2010; Bermejo, Capra et
al. 2011; Kume, Koyano et
al. 2011)
DNA damage checkpoint
(Schoemaker, Gayda
et al. 1984; Freudl, Braun et
al. 1987; Weinert and
Hartwell 1989; Weinert 1992; Weinert and
Hartwell 1993; Bridges 1995; Navas, Sanchez et
al. 1996; Higashitani,
Ishii et al. 1997; Longhese, Foiani
et al. 1998; Mukherjee, Cao et
al. 1998; Trusca, Scott et
al. 1998; Datta, Schmeits
et al. 2000; Foiani,
Pellicioli et al. 2000; Watanabe,
Morishita et al. 2002; Lisby and
Rothstein 2004; Parrilla-Castellar,
Arlander et al.
2004; Helt, Wang et al.
2005; Harrison and
Haber 2006; Ishikawa, Ishii
et al. 2006; Callegari and
Kelly 2007; Alao and
Sunnerhagen 2008; Barlow, Lisby et
al. 2008; Wood and Chen
2008; Xu,
Vaithiyalingam et al. 2008; Baker, Zeitlin et
al. 2010; Huen and Chen
2010; Warmerdam and
Kanaar 2010; Limbo,
Porter-Goff et al. 2011; Searle, Wood et
al. 2011)
Spindle checkpoint
(Hoyt 2001; Zhou, Yao et al.
2002; Lew and Burke
2003; Bharadwaj and Yu
2004; Taylor, Scott et
al. 2004; Pinsky and
Biggins 2005; Asakawa, Kume et
al. 2006; Norden, Mendoza
et al. 2006; Wang and Sun 2006; Musacchio and
Salmon 2007; Burke and
Stukenberg 2008; Clarke and
Bachant 2008; Fukagawa 2008; Varetti and
Musacchio 2008; Vogt,
Kirsch-Volders et al. 2008; Caillaud,
Paganelli et al. 2009; Doncic, Ben-Jacob
et al. 2009; Homer, Gui et al.
2009; Kang and Yu 2009; Kops 2009; Mendoza, Norden
et al. 2009; Nezi and
Musacchio 2009; Steigemann,
Wurzenberger et al. 2009; Vanoosthuyse and
Hardwick 2009; Caydasi, Ibrahim
et al. 2010; Vazquez-Novelle,
Mirchenko et al.
2010; Elowe 2011; Goto, Mishra et
al. 2011; Hoffman, Grashoff
et al. 2011; Rozelle, Hansen
et al. 2011)
Cell size checkpoint
(Rupes, Webb et
al. 2001; Donoso,
Munoz-Centeno et al. 2005; Fang, de los
Reyes et al. 2006)
Nuclear localization
(Lisby and
Rothstein 2004; Lisby and
Rothstein 2005)
REFERENCES
Alao, J. P. and
P. Sunnerhagen
(2008). "Rad3 and Sty1 function in Schizosaccharomyces
pombe: an
integrated response to DNA damage and environmental stress?"
Mol
Microbiol 68(2):
246-254. http://www.ncbi.nlm.nih.gov/pubmed/18366437.
Asakawa, K., K.
Kume, et al. (2006).
"The V260I mutation in fission yeast alpha-tubulin Atb2
affects
microtubule dynamics and EB1-Mal3 localization and activates
the Bub1 branch of
the spindle checkpoint." Mol Biol Cell 17(3): 1421-1435. http://www.ncbi.nlm.nih.gov/pubmed/16394105.
Baker, N. M., S.
G. Zeitlin, et al.
(2010). "Chromosome tips damaged in anaphase inhibit
cytokinesis." PLoS
One 5(8):
e12398. http://www.ncbi.nlm.nih.gov/pubmed/20811641.
Barlow, J. H., M.
Lisby, et al.
(2008). "Differential regulation of the cellular response to
DNA double-strand
breaks in G1." Mol Cell 30(1):
73-85. http://www.ncbi.nlm.nih.gov/pubmed/18406328.
Bermejo, R., T.
Capra, et al.
(2011). "The replication checkpoint protects fork stability
by releasing
transcribed genes from nuclear pores." Cell 146(2): 233-246. http://www.ncbi.nlm.nih.gov/pubmed/21784245.
Bharadwaj, R. and
H. Yu (2004).
"The spindle checkpoint, aneuploidy, and cancer." Oncogene
23(11):
2016-2027. http://www.ncbi.nlm.nih.gov/pubmed/15021889.
Branzei, D. and
M. Foiani (2009).
"The checkpoint response to replication stress." DNA
Repair (Amst)
8(9): 1038-1046.
http://www.ncbi.nlm.nih.gov/pubmed/19482564.
Bridges, B. A.
(1995). "Are
there DNA damage checkpoints in E. coli?" Bioessays
17(1): 63-70. http://www.ncbi.nlm.nih.gov/pubmed/7702595.
Burke, D. J. and
P. T. Stukenberg
(2008). "Linking kinetochore-microtubule binding to the
spindle
checkpoint." Dev Cell 14(4):
474-479. http://www.ncbi.nlm.nih.gov/pubmed/18410725.
Caillaud, M.
C., L. Paganelli, et al. (2009). "Spindle assembly
checkpoint protein
dynamics reveal conserved and unsuspected\ roles in plant
cell division." PLoS
One\ 4\(8\):
e6757\. http://www.ncbi.nlm.nih.gov/pubmed/19710914\.
Callegari, A.
J. and T. J. Kelly (2007). "Shedding light on the DNA damage
checkpoint." Cell Cycle 6(6):
660-666. http://www.ncbi.nlm.nih.gov/pubmed/17387276.
Caydasi, A.
K., B. Ibrahim, et al. (2010). "Monitoring spindle
orientation: Spindle
position checkpoint in charge." Cell Div 5: 28. http://www.ncbi.nlm.nih.gov/pubmed/21143992.
Ciapponi, L.
and G. Cenci (2008). "Telomere capping and cellular
checkpoints: clues
from fruit flies." Cytogenet Genome Res\ 122\(3-4\): 365-373\. http://www.ncbi.nlm.nih.gov/pubmed/19188707\.
Clarke, D. J.
and J. Bachant (2008). "Kinetochore structure and spindle
assembly
checkpoint signaling in the budding yeast, Saccharomyces
cerevisiae." Front
Biosci 13:
6787-6819. http://www.ncbi.nlm.nih.gov/pubmed/18508695.
Clelland, B.
W. and M. C. Schultz (2010). "Genome stability control by
checkpoint
regulation of tRNA gene transcription." Transcr 1(3): 115-125. http://www.ncbi.nlm.nih.gov/pubmed/21326884.
D'Urso, G.,
B. Grallert, et al. (1995). "DNA polymerase alpha, a
component of the
replication initiation complex, is essential for the
checkpoint coupling S
phase to mitosis in fission yeast." J Cell Sci 108 ( Pt 9): 3109-3118. http://www.ncbi.nlm.nih.gov/pubmed/8537450.
Datta, A., J.
L. Schmeits, et al. (2000). "Checkpoint-dependent activation
of mutagenic
repair in Saccharomyces cerevisiae\ pol3-01 mutants." Mol
Cell\ 6\(3\):
593-603\. http://www.ncbi.nlm.nih.gov/pubmed/11030339\.
Doncic, A.,
E. Ben-Jacob, et al. (2009). "Reverse engineering of the
spindle assembly
checkpoint." PLoS One 4(8):
e6495. http://www.ncbi.nlm.nih.gov/pubmed/19652707.
Donoso, I.,
M. C. Munoz-Centeno, et al. (2005). "Mpg1, a fission yeast
protein
required for proper septum structure, is involved in cell
cycle progression through
cell-size checkpoint." Mol Genet Genomics 274(2): 155-167. http://www.ncbi.nlm.nih.gov/pubmed/16049679.
Elledge, S.
J. (1996). "Cell cycle checkpoints: preventing an identity
crisis." Science\
274\(5293\):
1664-1672\. http://www.ncbi.nlm.nih.gov/pubmed/8939848\.
Elowe, S.
(2011). "Bub1 and BubR1: at the interface between chromosome
attachment
and the spindle checkpoint." Mol Cell Biol 31(15): 3085-3093. http://www.ncbi.nlm.nih.gov/pubmed/21628528.
Fang, S. C.,
C. de los Reyes, et al. (2006). "Cell size checkpoint
control by the
retinoblastoma tumor suppressor pathway." PLoS Genet\
2\(10\): e167\. http://www.ncbi.nlm.nih.gov/pubmed/17040130\.
Foiani, M.,
A. Pellicioli, et al. (2000). "DNA damage checkpoints and
DNA replication
controls in Saccharomyces cerevisiae." Mutat Res\ 451\(1-2\):
187-196\. http://www.ncbi.nlm.nih.gov/pubmed/10915872\.
Freudl, R.,
G. Braun, et al. (1987). "Evolution of the enterobacterial
sulA gene: a
component of the SOS system encoding an inhibitor of cell
division." Gene
52(1): 31-40. http://www.ncbi.nlm.nih.gov/pubmed/3297925.
Fukagawa, T.
(2008). "The kinetochore and spindle checkpoint in
vertebrate cells."
Front Biosci 13:
2705-2713. http://www.ncbi.nlm.nih.gov/pubmed/17981745.
Fuller, B. G.
and P. T. Stukenberg (2009). "Cell division: righting the
check." Curr
Biol 19(14):
R550-553. http://www.ncbi.nlm.nih.gov/pubmed/19640489.
Game, J. C.
and S. B. Chernikova (2009). "The role of RAD6 in
recombinational repair,
checkpoints and meiosis via histone modification." DNA
Repair (Amst)
8(4): 470-482. http://www.ncbi.nlm.nih.gov/pubmed/19230796.
Goto, G. H.,
A. Mishra, et al. (2011). "Bub1-mediated adaptation of the
spindle
checkpoint." PLoS Genet 7(1):
e1001282. http://www.ncbi.nlm.nih.gov/pubmed/21298086.
Hansen, D.
and T. Schedl (2006). "The regulatory network controlling
the
proliferation-meiotic entry decision in the Caenorhabditis
elegans germ
line." Curr Top Dev Biol 76:
185-215. http://www.ncbi.nlm.nih.gov/pubmed/17118267.
Harrison, J.
C. and J. E. Haber (2006). "Surviving the breakup: the DNA
damage
checkpoint." Annu Rev Genet 40:
209-235. http://www.ncbi.nlm.nih.gov/pubmed/16805667.
Hartwell, L.
(1992). "Defects in a cell cycle checkpoint may be
responsible for the
genomic instability of cancer cells." Cell 71(4): 543-546. http://www.ncbi.nlm.nih.gov/pubmed/1423612.
Hartwell, L.,
Weinert, TA (1989). "Checkpoints: controls that ensure the
order of cell
cycle events." Science 246:
629-634. http://www.ncbi.nlm.nih.gov/pubmed/2683079.
Hartwell, L.
H. (2004). "Yeast and cancer." Biosci Rep 24(4-5): 523-544. http://www.ncbi.nlm.nih.gov/pubmed/16134024.
Helt, C. E.,
W. Wang, et al. (2005). "Evidence that DNA damage detection
machinery
participates in DNA repair." Cell Cycle 4(4): 529-532. http://www.ncbi.nlm.nih.gov/pubmed/15876866.
Higashitani,
A., Y. Ishii, et al. (1997). "Functional dissection of a
cell-division
inhibitor, SulA, of Escherichia coli and its negative
regulation by Lon." Mol
Gen Genet 254(4):
351-357. http://www.ncbi.nlm.nih.gov/pubmed/9180687.
Hoffman, B.
D., C. Grashoff, et al. (2011). "Dynamic molecular processes
mediate
cellular mechanotransduction." Nature 475(7356): 316-323. http://www.ncbi.nlm.nih.gov/pubmed/21776077.
Homer, H., L.
Gui, et al. (2009). "A spindle assembly checkpoint protein
functions in
prophase I arrest and prometaphase progression." Science
326(5955):
991-994. http://www.ncbi.nlm.nih.gov/pubmed/19965510.
Hoyt, M. A.
(2001). "A new view of the spindle checkpoint." J Cell
Biol 154(5):
909-911. http://www.ncbi.nlm.nih.gov/pubmed/11535614.
Huen, M. S.
and J. Chen (2010). "Assembly of checkpoint and repair
machineries at DNA
damage sites." Trends Biochem Sci 35(2): 101-108. http://www.ncbi.nlm.nih.gov/pubmed/19875294.
Ishikawa, K.,
H. Ishii, et al. (2006). "DNA damage-dependent cell cycle
checkpoints and
genomic stability." DNA Cell Biol 25(7): 406-411. http://www.ncbi.nlm.nih.gov/pubmed/16848682.
Kang, J. and
H. Yu (2009). "Kinase signaling in the spindle checkpoint."
J Biol
Chem 284(23):
15359-15363. http://www.ncbi.nlm.nih.gov/pubmed/19228686.
Kops, G. J.
(2009). "Dividing the goods: co-ordination of chromosome
biorientation and
mitotic checkpoint signalling by mitotic kinases." Biochem
Soc Trans
37(Pt 5):
971-975. http://www.ncbi.nlm.nih.gov/pubmed/19754434.
Kume, K., T.
Koyano, et al. (2011). "Calcineurin ensures a link between
the DNA
replication checkpoint and microtubule-dependent polarized
growth." Nat
Cell Biol. http://www.ncbi.nlm.nih.gov/pubmed/21336311.
Lew, D. J.
and D. J. Burke (2003). "The spindle assembly and spindle
position
checkpoints." Annu Rev Genet 37:
251-282. http://www.ncbi.nlm.nih.gov/pubmed/14616062.
Limbo, O., M.
E. Porter-Goff, et al. (2011). "Mre11 nuclease activity and
Ctp1 regulate
Chk1 activation by Rad3ATR and Tel1ATM checkpoint kinases at
double-strand
breaks." Mol Cell Biol 31(3):
573-583. http://www.ncbi.nlm.nih.gov/pubmed/21098122.
Lisby, M. and
R. Rothstein (2004). "DNA damage checkpoint and repair
centers." Curr
Opin Cell Biol 16(3):
328-334. http://www.ncbi.nlm.nih.gov/pubmed/15145359.
Lisby, M. and
R. Rothstein (2005). "Localization of checkpoint and repair
proteins in
eukaryotes." Biochimie 87(7):
579-589. http://www.ncbi.nlm.nih.gov/pubmed/15989975.
Longhese, M.
P., M. Foiani, et al. (1998). "DNA damage checkpoint in
budding
yeast." Embo J\ 17\(19\):
5525-5528\. http://www.ncbi.nlm.nih.gov/pubmed/9755152\.
McAdams, H.
H. and L. Shapiro (2009). "System-level design of bacterial
cell cycle
control." FEBS Lett 583(24):
3984-3991. http://www.ncbi.nlm.nih.gov/pubmed/19766635.
Mendoza, M.,
C. Norden, et al. (2009). "A mechanism for chromosome
segregation sensing
by the NoCut checkpoint." Nat Cell Biol 11(4): 477-483. http://www.ncbi.nlm.nih.gov/pubmed/19270692.
Mukherjee,
A., C. Cao, et al. (1998). "Inhibition of FtsZ
polymerization by SulA, an
inhibitor of septation in Escherichia coli." Proc Natl
Acad Sci U S A
95(6): 2885-2890.
http://www.ncbi.nlm.nih.gov/pubmed/9501185.
Musacchio, A.
and E. D. Salmon (2007). "The spindle-assembly checkpoint in
space and
time." Nat Rev Mol Cell Biol 8(5):
379-393. http://www.ncbi.nlm.nih.gov/pubmed/17426725.
Navas, T. A.,
Y. Sanchez, et al. (1996). "RAD9 and DNA polymerase epsilon
form parallel
sensory branches for transducing the DNA damage checkpoint
signal in
Saccharomyces cerevisiae." Genes Dev 10(20): 2632-2643. http://www.ncbi.nlm.nih.gov/pubmed/8895664.
Navas, T. A.,
Z. Zhou, et al. (1995). "DNA polymerase epsilon links the
DNA replication
machinery to the S phase checkpoint." Cell 80(1): 29-39. http://www.ncbi.nlm.nih.gov/pubmed/7813016.
Nezi, L. and
A. Musacchio (2009). "Sister chromatid tension and the
spindle assembly
checkpoint." Curr Opin Cell Biol 21(6): 785-795. http://www.ncbi.nlm.nih.gov/pubmed/19846287.
Nguyen, V.
C., B. W. Clelland, et al. (2010). "Replication stress
checkpoint
signaling controls tRNA gene transcription." Nat Struct
Mol Biol 17(8):
976-981. http://www.ncbi.nlm.nih.gov/pubmed/20639887.
Norden, C.,
M. Mendoza, et al. (2006). "The NoCut pathway links
completion of
cytokinesis to spindle midzone function to prevent
chromosome breakage." Cell
125(1): 85-98. http://www.ncbi.nlm.nih.gov/pubmed/16615892.
Parrilla-Castellar,
E.
R., S. J. Arlander, et al. (2004). "Dial 9-1-1 for DNA
damage: the
Rad9-Hus1-Rad1 (9-1-1) clamp complex." DNA Repair (Amst)
3(8-9):
1009-1014. http://www.ncbi.nlm.nih.gov/pubmed/15279787.
Paulovich, A.
G. and L. H. Hartwell (1995). "A checkpoint regulates the
rate of
progression through S phase in S. cerevisiae in response to
DNA damage." Cell
82(5): 841-847. http://www.ncbi.nlm.nih.gov/pubmed/7671311.
Pinsky, B. A.
and S. Biggins (2005). "The spindle checkpoint: tension
versus
attachment." Trends Cell Biol 15(9):
486-493. http://www.ncbi.nlm.nih.gov/pubmed/16084093.
Putnam, C.
D., E. J. Jaehnig, et al. (2009). "Perspectives on the DNA
damage and
replication checkpoint responses in Saccharomyces
cerevisiae." DNA
Repair (Amst) 8(9):
974-982. http://www.ncbi.nlm.nih.gov/pubmed/19477695.
Rozelle, D.
K., S. D. Hansen, et al. (2011). "Chromosome passenger
complexes control
anaphase duration and spindle elongation via a kinesin-5
brake." J Cell
Biol 193(2):
285-294. http://www.ncbi.nlm.nih.gov/pubmed/21482719.
Rupes, I., B.
A. Webb, et al. (2001). "G2/M arrest caused by actin
disruption is a
manifestation of the cell size checkpoint in fission yeast."
Mol Biol
Cell 12(12):
3892-3903. http://www.ncbi.nlm.nih.gov/pubmed/11739788.
Schoemaker,
J. M., R. C. Gayda, et al. (1984). "Regulation of cell
division in
Escherichia coli: SOS induction and cellular location of the
sulA protein, a
key to lon-associated filamentation and death." J
Bacteriol 158(2):
551-561. http://www.ncbi.nlm.nih.gov/pubmed/6327610.
Sclafani, R.
A. and T. M. Holzen (2007). "Cell cycle regulation of DNA
replication." Annu Rev Genet 41:
237-280. http://www.ncbi.nlm.nih.gov/pubmed/17630848.
Searle, J.
S., M. D. Wood, et al. (2011). "Proteins in the
Nutrient-Sensing and DNA
Damage Checkpoint Pathways Cooperate to Restrain Mitotic
Progression following
DNA Damage." PLoS Genet 7(7):
e1002176. http://www.ncbi.nlm.nih.gov/pubmed/21779180.
Segurado, M.
and J. A. Tercero (2009). "The S-phase checkpoint: targeting
the
replication fork." Biol Cell 101(11):
617-627. http://www.ncbi.nlm.nih.gov/pubmed/19686094.
Steigemann,
P., C. Wurzenberger, et al. (2009). "Aurora B-mediated
abscission
checkpoint protects against tetraploidization." Cell
136(3): 473-484.
http://www.ncbi.nlm.nih.gov/pubmed/19203582.
Taylor, S.
S., M. I. Scott, et al. (2004). "The spindle checkpoint: a
quality control
mechanism which ensures accurate chromosome segregation." Chromosome
Res 12(6):
599-616. http://www.ncbi.nlm.nih.gov/pubmed/15289666.
Trusca, D.,
S. Scott, et al. (1998). "Bacterial SOS checkpoint protein
SulA inhibits
polymerization of purified FtsZ cell division protein." J
Bacteriol
180(15):
3946-3953. http://www.ncbi.nlm.nih.gov/pubmed/9683493.
Vanoosthuyse,
V. and K. G. Hardwick (2009). "Overcoming inhibition in the
spindle
checkpoint." Genes Dev 23(24):
2799-2805. http://www.ncbi.nlm.nih.gov/pubmed/20008930.
Varetti, G.
and A. Musacchio (2008). "The spindle assembly checkpoint."
Curr
Biol 18(14):
R591-595. http://www.ncbi.nlm.nih.gov/pubmed/18644330.
Vazquez-Novelle,
M. D., L. Mirchenko, et al. (2010). "The 'anaphase problem':
how to
disable the mitotic checkpoint when sisters split." Biochem
Soc Trans
38(6): 1660-1666.
http://www.ncbi.nlm.nih.gov/pubmed/21118144.
Vogt, E., M.
Kirsch-Volders, et al. (2008). "Spindle formation,
chromosome segregation
and the spindle checkpoint in mammalian oocytes and
susceptibility to meiotic
error." Mutat Res 651(1-2):
14-29. http://www.ncbi.nlm.nih.gov/pubmed/18096427.
Voineagu, I.,
C. H. Freudenreich, et al. (2009). "Checkpoint responses to
unusual
structures formed by DNA repeats." Mol Carcinog 48(4): 309-318. http://www.ncbi.nlm.nih.gov/pubmed/19306277.
Wang, W. H.
and Q. Y. Sun (2006). "Meiotic spindle, spindle checkpoint
and embryonic
aneuploidy." Front Biosci 11:
620-636. http://www.ncbi.nlm.nih.gov/pubmed/16146756.
Warmerdam, D.
O. and R. Kanaar (2010). "Dealing with DNA damage:
relationships between
checkpoint and repair pathways." Mutat Res 704(1-3): 2-11. http://www.ncbi.nlm.nih.gov/pubmed/20006736.
Watanabe, K.,
J. Morishita, et al. (2002). "Involvement of RAD9-dependent
damage
checkpoint control in arrest of cell cycle, induction of cell death, and
chromosome instability caused
by defects in origin recognition complex in Saccharomyces
cerevisiae." Eukaryot
Cell 1(2):
200-212. http://www.ncbi.nlm.nih.gov/pubmed/12455955.
Weinert, T.
and L. Hartwell (1989). "Control of G2 delay by the rad9
gene of
Saccharomyces cerevisiae." J Cell Sci Suppl 12: 145-148. http://www.ncbi.nlm.nih.gov/pubmed/2699734.
Weinert, T.
A. (1992). "Dual cell cycle checkpoints sensitive to
chromosome
replication and DNA damage in the budding yeast
Saccharomyces cerevisiae."
Radiat Res 132(2):
141-143. http://www.ncbi.nlm.nih.gov/pubmed/1438694.
Weinert, T.
A. and L. H. Hartwell (1993). "Cell cycle arrest of cdc
mutants and
specificity of the RAD9 checkpoint." Genetics 134(1): 63-80. http://www.ncbi.nlm.nih.gov/pubmed/8514150.
Wood, J. L.
and J. Chen (2008). "DNA-damage checkpoints: location,
location,
location." Trends Cell Biol\ 18\(10\):
451-455\. http://www.ncbi.nlm.nih.gov/pubmed/18760607\.
Xu, X., S.
Vaithiyalingam, et al. (2008). "The basic cleft of RPA70N
binds multiple
checkpoint proteins, including RAD9, to regulate ATR
signaling." Mol
Cell Biol 28(24):
7345-7353. http://www.ncbi.nlm.nih.gov/pubmed/18936170.
Zhou, J., J.
Yao, et al. (2002). "Attachment and tension in the spindle
assembly
checkpoint." J Cell Sci 115(Pt
18): 3547-3555. http://www.ncbi.nlm.nih.gov/pubmed/12186941.